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DismissedNational Interest Waiver · Appeal

Post-doctoral neurodevelopment and neurological disease treatment researcher

Biomedical & life sciences · decided 2026-02-25 · SCOPS · FEB252026_04B5203

Official PDF on uscis.gov

How each part of the test was decided

Read from the appeals office's own sentences by fixed rules, not from the Director's findings or the petitioner's arguments. Each result shows the sentence it came from. The official PDF controls.

  • Step 0Eligible for EB-2Not decided

    No finding on this in the appeals office's own words.

  • Prong 1Merit and national importanceMet
    Why
    We conclude the Petitioner has demonstrated the national importance of her proposed endeavor under the first prong of the Dhanasar framework. 2 B. p. 3
  • Prong 2Well positioned to advance itNot met
    Why
    Because the evidence in the record does not establish that she is well positioned to advance her proposed endeavor as required by the second prong ofthe Dhanasar precedent decision, the Petitioner has not demonstrated her eligibility for a national interest waiver. p. 6
  • Prong 3Worth waiving the job offerNot decided

    No finding on this in the appeals office's own words.

The decision in brief

Sentences picked out of the text automatically. Read them in context below; the official PDF controls.

Summary sentence

Service Center Operations (SCOPS) denied the petition, concluding the record did not establish that a waiver of the required job offer, and thus of a labor certification, would be in the national interest. See in text

What the AAO decided

Main reasons given

  • We conclude the Petitioner has demonstrated the national importance of her proposed endeavor under the first prong of the Dhanasar framework. 2 B. See in text
  • For the reasons discussed below, we conclude the Petitioner's endeavor is substantially meritorious and nationally important. See in text
  • So, we conclude that the Petitioner has not established eligibility for a national interest waiver under the analytical framework set forth in Dhanasar. See in text
Show 3 more
  • For the aforementioned reasons, the Petitioner has not satisfied the second prong of the Dhanasar analytical framework. See in text
  • Because the evidence in the record does not establish that she is well positioned to advance her proposed endeavor as required by the second prong ofthe Dhanasar precedent decision, the Petitioner has not demonstrated her eligibility for a national interest waiver. See in text
  • The sole issue to be determined is whether the Petitioner has established that a waiver of the requirement of a job offer, and thus of a labor certification, would be in the national interest. See in text
Read the full decision (6 pages)

Objections found (4)

Automated tags. Each shows the sentence that triggered it.

  • But SCOPS concluded the Petitioner's endeavor was not nationally important because the evidence did not demonstrate "a significant potential to employ U.S. workers or [describe] other substantial positive economic effects, particularly in an economically depressed area as the [Petitioner] continues her employment with I as a postdoctoral scholar." See in text (p. 2)
  • The Petitioner submitted eight letters of recommendation into the record. 5 The letters generally discuss the Petitioner's past and/or current research. See in text (p. 5)
  • Well Positioned To Advance The Proposed Endeavor In determining whether a petitioner meets Dhanasar 's second prong, "we consider factors including, but not limited to: the individual's education, skills, knowledge, and record of success in related or similar efforts; a model or plan for future activities; any progress towards achieving the proposed endeavor; and the interest of potential customers, users, investors, or other relevant entities or individuals." See in text (p. 3)
  • So, the compact does not demonstrate an interest in her proposed endeavor or highlight future progress in achieving its objectives such that it could establish how well-positioned the Petitioner is to advance her proposed endeavor. See in text (p. 5)

Full decision

OCR text from the official PDF, reformatted for reading. Scan errors carry over; the PDF controls.

Highlighted: Outcome (2) AAO finding (6) Tagged objection (4)Matter of X citation
Decision header
U.S. Citizenship and Immigration Services · Non-Precedent Decision of the Administrative Appeals Office · In Re: 40989600 Date: FEB. 25, 2026 · Appeal of Service Center Operations (SCOPS) Decision · Form 1-140, Immigrant Petition for Alien Workers (National Interest Waiver)

The Petitioner, a post-doctoral neurodevelopment and neurological disease treatment researcher, seeks employment-based second preference (EB-2) immigrant classification as a member of the professions holding an advanced degree, as well as a national interest waiver of the job offer requirement attached to this classification. See Immigration and Nationality Act (the Act) section 203(b)(2), 8 U.S.C. § 1153(b)(2).

Service Center Operations (SCOPS) denied the petition, concluding the record did not establish that a waiver of the required job offer, and thus of a labor certification, would be in the national interest. The matter is now before us on appeal pursuant to 8 C.F.R. § 103.3.

The Petitioner bears the burden ofproof to demonstrate eligibility by a preponderance of the evidence. Matter ofChawathe, 25 I&N Dec. 369, 375-76 (AAO 2010). We review the questions in this matter de novo. Matter of Christa's, Inc., 26 I&N Dec. 537,537 n.2 (AAO 2015). Upon de novo review, we will dismiss the appeal.

Law

To qualify for the underlying EB-2 visa classification, a petitioner must establish he or she is an advanced degree professional or an individual of exceptional ability in the sciences, arts, or business. Section 203(b )(2)(A) of the Act.

Ifa petitioner establishes eligibility for the underlying EB-2 classification, they must then demonstrate that they merit a discretionary waiver of the job offer requirement "in the national interest." Section 203(b )(2)(B)(i) ofthe Act. Matter ofDhanasar, 26 I&N Dec. 884, 889 (AAO 2016), provides the framework for adjudicating national interest waiver petitions. Dhanasar states that U.S. Citizenship and Immigration Services (USCIS) may, as matter of discretion, 1 grant a national interest waiver if the petitioner demonstrates that:

  • The proposed endeavor has both substantial merit and national importance;
  • The individual is well-positioned to advance their proposed endeavor; and
  • On balance, waiving the job offer requirement would benefit the United States.

Id.

Analysis

SCOPS concluded that the Petitioner qualified as a member of the professions holding an advanced degree. The sole issue to be determined is whether the Petitioner has established that a waiver of the requirement of a job offer, and thus of a labor certification, would be in the national interest. At the time of filing, the Petitioner was conducting neurodevelopment and neurological disease treatment research as a postdoctoral scholar at I I The Petitioner proposed to endeavor to research SATB2-Associated Syndrome (SAS) by introducing SAS mutations into mouse models through clustered regularly interspaced short palindromic repeats (CRISPR) based iGONAD technology. The Petitioner also proposed to extend her work to farther study related neurodevelopmental disorders caused by point mutations or intragenetic rearrangement of genes in genome such as Rett syndrome or Fragile X syndrome.

For the reasons discussed below, we conclude the Petitioner's endeavor is substantially meritorious and nationally important. But the evidence in the record does not adequately demonstrate that the Petitioner is well positioned to advance her proposed endeavor. So, we conclude that the Petitioner has not established eligibility for a national interest waiver under the analytical framework set forth in Dhanasar.

A. Substantial Merit and National Importance

The first prong, substantial merit and national importance, focuses on the specific endeavor that the individual proposes to undertake. As stated above, the endeavor's merit may be demonstrated in a range ofareas such as business, entrepreneurialism, sciences, technology, culture, health, or education. In determining whether the proposed endeavor has national importance, we consider its potential prospective impact. Dhanasar, 26 I&N Dec. at 889.

SCOPS determined that the Petitioner provided sufficient evidence to establish the substantially meritorious nature of their proposed endeavor. But SCOPS concluded the Petitioner's endeavor was not nationally important because the evidence did not demonstrate "a significant potential to employ U.S. workers or [describe] other substantial positive economic effects, particularly in an economically depressed area as the [Petitioner] continues her employment with I as a postdoctoral scholar."Job creation or economic claims unsupported

But in Dhanasar we did not require endeavors to demonstrate a significant potential to employ U.S. workers or other substantial positive economic effects particularly in economically depressed areas. We only stated that endeavors that feature those attributes could, for instance, be understood to have national importance. The potential prospective impact of undertakings or endeavors could demonstrate impact on a level of national importance because of national or even global implications within a particular field, such as those resulting from certain improved manufacturing processes or I p. 3 medical advances. And broader implications of a proposed endeavor, national and/or international, can also inform us of the proposed endeavor's national importance. Broader implications are not necessarily viewed solely through a geographical lens. Broader implications can reach beyond a particular proposed endeavor's geographical locus and focus. The relevant inquiry is whether the broader implications apply beyond just narrowly conferring the proposed endeavor's benefit. SCOPS noted that the Petitioner submitted multiple articles, studies, and reports to support her claim of eligibility under Dhanasar 's first prong. And SCOPS indicated that the Petitioner claimed economic prosperity and national security as benefits of her endeavor along with how the application of neuroscience can improve the physical well-being and health of Americans. But the Petitioner's detailed statement of her endeavor described her research and its potential prospective impact on neurodevelopment and neurological disease treatment. Further examination of the evidence the Petitioner submitted uncovered that the Petitioner proposed to research the molecular mechanisms underlying SAS with an aim to develop targeted therapies for it and expanding her research to related neurodevelopmental disorders. And the Petitioner submitted probative letters of support from experts in her field of neurodevelopmental disorders and neurological disease treatment at various accredited national and international institutions of higher education which meaningfully described the neurodevelopment and neurological disease treatment work described in the Petitioner's proposed endeavor and its potential prospective impact on how neuronal networks precisely control movement and behavior. Other letters farther discussed how uncovering cellular mechanisms driving neurodevelopmental disorders through the proposed endeavor could support the development of targeted therapies. Additionally, the Petitioner submitted documentation demonstrating broader implications on the field from her proposed research, as the results of it were and are intended to continue to be disseminated to others in the field through academic journals in the field. The Petitioner's assertions are supported by material, relevant, and probative evidence demonstrating both the substantial merit and national importance of her proposed research. So, whilst we agree with the Director's conclusion that the Petitioner demonstrated its substantial merit, we disagree with the Director's conclusion regarding the national importance of the Petitioner's proposed endeavor and withdraw it. We conclude the Petitioner has demonstrated the national importance of her proposed endeavor under the first prong of the Dhanasar framework. 2 B. Well Positioned To Advance The Proposed EndeavorPast record does not show influence or success

In determining whether a petitioner meets Dhanasar 's second prong, "we consider factors including, but not limited to: the individual's education, skills, knowledge, and record of success in related or similar efforts; a model or plan for future activities; any progress towards achieving the proposed endeavor; and the interest of potential customers, users, investors, or other relevant entities or individuals." Id. at 890.

The record includes two versions ofthe Petitioner's personal statement, her curriculum vitae, academic records (including her Ph.D. in biology), published and presented work, and peer review. In addition, the Petitioner provided her Google Scholar profile, documentation ofarticles that citied to her research 2 The Petitioner's petition support letter identifies "mentoring and training the next generation of scientists" as a "key aspect" ofher proposed endeavor. This is akin to teaching. But the benefit of someone's teaching is generally only directly beneficial to the students being taught and not the wider population. In Dhanasar we discussed how teaching would not impact a field broadly in a manner which rises to national importance. Id at 893. p. 4 findings, articles supporting the merits of neurodevelopment and neurological disease treatment research, and personal letters of support. 3

We note that the Petitioner earned a Ph.D. in biology and was participating in a postdoctoral fellowship at th-.____

~------------' at the time of filing the underlying petition. We note that USCIS considers an advanced degree, particularly a Doctor of Philosophy (Ph.D.), in a STEM field tied to the proposed endeavor and related to work furthering a critical and emerging technology or other STEM area important to competitiveness or national security, an especially positive factor to be considered along with other evidence for purposes of the assessment under the second prong." See 6 USCIS Policy Manual F.5(D)(2), https://www.uscis.gov/policy-manual. But the Petitioner has not adequately demonstrated that her academic accomplishments by themselves are sufficient to demonstrate that she is well positioned to advance her proposed endeavor. We look at a variety of factors in determining whether a petitioner is well positioned to advance their proposed endeavor, and education is one factor among many that may contribute to such a finding.

Regarding the Petitioner's invitations to serve and service as a peer reviewer, she submitted several emails acknowledging her peer review service from editorial boards for several journals. The record also contains a copy of a webpage on elsevier.com discussing how it relies on the peer review process to uphold the quality and validity of individual articles and peer review's value as a form of scientific evaluation. The record does not indicate how the Petitioner's participation in a peer review process for Elsevier published journals or others represented a record of success in her field or is otherwise an indication that she is well-positioned to advance her proposed endeavor.

The record demonstrates that the Petitioner has conducted research and published her conclusions in scholarly articles in academic journals. And the Petitioner has submitted several personal letters of support describing her past and present research and its potential positive outcomes. But the Petitioner has not demonstrated that this research work renders her well positioned to advance her proposed endeavor. Whilst we recognize that research must add information to the pool of knowledge in some way to be accepted for publication, presentation, funding, or academic credit, not every individual who has performed original research will be found to be well positioned to advance their proposed endeavor. Rather, we examine the factors set forth in Dhanasar to determine whether, for instance, the individual's progress towards achieving the goals of the proposed research, record of success in similar efforts, or generation of interest among relevant parties support such a finding. Id. at 890. The Petitioner here, however, has not sufficiently demonstrated that her published and presented work has served as an impetus for progress in neurodevelopmental and neurological disease treatment research. The Petitioner contends that she "has published in top journals in her field and her work is highly cited." The record contains a Google Scholar profile which reflects the Petitioner authored or coauthored seven articles between 2009 and 2021. Three articles she co-authored between 2009 and 2018 account for over half of her total citations, or 271 out of 456 citations. The next highest cited paper the Petitioner authored or co-authored was in 2011. The Petitioner provided Elsevier's citation and abstract database, Scopus, to aver that the Petitioner "has multiple publications that are highly cited compared to others in her field." Specifically, the Petitioner discussed the "Field-Weighted Citation Impact (FCWI)" oftwo articles the Petitioner authored or co-authored in 2009 and 2021. The 3 Whilst we may not discuss every document submitted, we have reviewed and considered each one. p. 5 Petitioner contends that demonstrating her total rate of citation is high relative to others in the field indicates her high overall standing to demonstrate that she is among the small percentage at the top of her field. 4 But, an individual's claim to some high stature in his or her field, without more, is not probative to the question of how well positioned he or she may be to advance his or her proposed endeavor. In Dhanasar, we stated we consider an individual's education, skills, knowledge, and record of success in related or similar efforts; a model or plan for future activities; any progress towards achieving the proposed endeavor; and the interest of potential customers, users, investors, or other relevant entities or individuals" to determine how well-positioned the individual is to advance his or her proposed endeavor. Id. at 890.

The Petitioner asserts that her proposed endeavor has received fonding from the I._________. _________ __. The record contains a co of a "Trainee and Mentor Pro act" issued to the Petitioner from the c=J. But the "compact" descri .... b-es-th_a_t-th_e_'=====,....f_e_ll_o_w_s_h-ip-is_a_fo_n_d_i_n_g_s_o_u_rc_e_o_n_ly-,-,a-n-d-th_a_t-it-is_. to "request initiation of [her] fellowship." Or, in other words, the "compact" describes the Petitioner's fonding source for her post-doctoral training. So, the compact does not demonstrate an interest in her proposed endeavor or highlight future progress in achieving its objectives such that it could establish how well-positioned the Petitioner is to advance her proposed endeavor.No interest from users, customers or investors

The Petitioner submitted eight letters of recommendation into the record. 5 The letters generally discuss the Petitioner's past and/or current research.Support letters generic or unsupported For example! I assistant professor, brain and mind research institute,.__________~ stated the Petitioner "completed research on neuronal regeneration after brain ischemia-hypoxia injury." I Ialso stated that the Petitioner's current "research focuses on the impact of cerebral cortex development on its functions, particularly exploring the mechanisms by which different mutations of the SATB2 gene influence individual development." Andi l assistant research professor,! Istated that whilst he has not "cited her articles [he is] familiar with her research" and states her research has "provide[d] many potential candidate IncRNAs genes related to brain neural development."

Additionally, I Idistinguished professor, I I described the Petitioner's work in his research group in the areas of "gene expression and epigenetic modifications regulating brain development." Also) I a professor and colleague of the Petitioner at the I Idescribes the Petitioner's and his joint "research in the area of cerebral cortex development" and describes her skills, knowledge, and prior research success. professor,

So, as stated above, the letters the Petitioner submitted into the record serve as summaries describing the Petitioner's past and/or current research, credit her with certain published research observations, and in some cases have cited her work. But the letters do not elaborate on how the Petitioner's research observations support how well she is positioned to advance her proposed endeavor. Or in other words, the Petitioner's letters do not demonstrate that her research findings constitute a record of success or progress rendering her well positioned to advance her proposed endeavor. Nor do the summaries adequately highlight how the Petitioner's research, research observations, and citations to her work support her progress towards achieving her proposed endeavor or any interest in her proposed endeavor at a level that describes how well positioned she is to advance it.

Conclusion

For the aforementioned reasons, the Petitioner has not satisfied the second prong of the Dhanasar analytical framework. Because the evidence in the record does not establish that she is well positioned to advance her proposed endeavor as required by the second prong ofthe Dhanasar precedent decision, the Petitioner has not demonstrated her eligibility for a national interest waiver. Since this issue is dispositive of the Petitioner's appeal, we decline to reach and hereby reserve the appellate arguments regarding her eligibility under the third prong outlined in Dhanasar. See INS v. Bagamasbad, 429 U.S. 24, 25 (1976) ("courts and agencies are not required to make findings on issues the decision of which is unnecessary to the results they reach"); see also Matter ofL-A-C-, 26 I&N Dec. 516, 526 n.7 (BIA 2015) (declining to reach alternative issues on appeal where an applicant is otherwise ineligible). ORDER: The appeal is dismissed.

NOTICE: This constitutes the final decision in this matter. The filing of a motion will not postpone the effect of the decision. 8 C.F.R. § 103.5(a)(l)(iv). Aliens who are not lawfully present, or who are otherwise inadmissible or deportable, may be subject to the commencement of removal proceedings under section 240 ofthe Act through the issuance ofa Form 1-862, Notice to Appear. Those proceedings may result in their removal from the United States and possible ineligibility for future visas or other immigration benefits.